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DISCOVERY: Can cancer be treated like an infection?Find out how researchers at the Princess Margaret are mimicking a...

Posted by University Health Network on Thursday, August 27, 2015
 

Use of irreversible electroporation (IRE) doubles the survival time for patients with locally advanced pancreatic cancer say researchers at the University of Louisville in a paper in the September edition of the Annals of Surgery.

“The appropriate and precise use of IRE in appropriately selected patients with locally advanced pancreatic cancer can result in a median overall survival close to 24 months, which is nearly double the survival rate with the best new chemotherapy and chemo-radiotherapy,” said Robert Martin, M.D., Ph.D., director of surgical oncology at UofL.

High-grade serous ovarian cancer often responds well to the chemotherapy drug carboplatin, but why it so frequently comes back after treatment has been a medical mystery.

Now a team of UCLA researchers has discovered that a subset of tumor cells that don’t produce the protein CA125, a biomarker used to test for ovarian cancer, has an enhanced ability to repair their DNA and resist programmed cell death — which allows the cells to evade the drug and live long enough to regrow the original tumor.

Resveratrol and quercetin, two polyphenols that have been widely studied for their health properties, may soon become the basis of an important new advance in cancer treatment, primarily by improving the efficacy and potential use of an existing chemotherapeutic cancer drug.

Resveratrol, a powerful antioxidant found in red wine and other foods, has already received much attention as a possible explanation for the “French paradox,” a low incidence of cardiovascular disease despite a diet often high in fats.

The new research suggests it may soon have value far beyond that.

  • ‘Unbelievable’ success for small pilot study
  • Treatment buys critical time for patients seeking potentially life-saving transplant
  • Cutting-edge combo pairs immune therapy, manipulation of gene activity
  • Drugs already approved by the Food and Drug Administration
  • Study ‘proof of principle’ for treating many other cancers as well

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