The substance wogonin triggers the death program apoptosis in tumor cells, while it has virtually no effect on healthy cells. Scientists of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have discovered the molecular mechanism underlying this selectivity.
Due to defects in chromosomal distribution, a majority of tumor cells would not be able to survive were it not for a trick that cancer cells have developed to avoid this chaos in the genetic material. Scientists of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have discovered that the antibiotic griseofulvin counteracts this tactic of tumors and, thus, forces cancer cells into cell death.
A mouse resistant to cancer, even highly-aggressive types, has been created by researchers at the University of Kentucky. The breakthrough stems from a discovery by UK College of Medicine professor of radiation medicine Vivek Rangnekar and a team of researchers who found a tumor-suppressor gene called "Par-4" in the prostate.