The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication, and is a prime target of antibacterial and anticancer drugs. Researchers with the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) at Berkeley have produced the first three-dimensional structural images of a DNA-bound Type II topoisomerase (topo II) that is responsible for untangling coiled strands of the chromosome during cell division.
Talcum powder has been used for generations to soothe babies' diaper rash and freshen women's faces. But University of Florida researchers report the household product has an additional healing power: The ability to stunt cancer growth by cutting the flow of blood to metastatic lung tumors.
Resent research at the University of Haifa found that molecules found in common fungus Ganoderma lucidum aid in suppressing some of the mechanisms involved in the progression of prostate cancer. The main action of the fungus: disrupting androgen receptor activity and impeding the proliferation of cancerous cells.
The substance wogonin triggers the death program apoptosis in tumor cells, while it has virtually no effect on healthy cells. Scientists of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have discovered the molecular mechanism underlying this selectivity.
Due to defects in chromosomal distribution, a majority of tumor cells would not be able to survive were it not for a trick that cancer cells have developed to avoid this chaos in the genetic material. Scientists of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have discovered that the antibiotic griseofulvin counteracts this tactic of tumors and, thus, forces cancer cells into cell death.